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Wednesday, November 20, 2019

Bourgeoisophobes

Among the Bourgeoisophobes, Part 2
by David Brooks 


04/06/2002 12:03:00 AM


THE BRUTALIST bourgeoisophobia of the Islamic extremists is pretty straightforward. The attitudes of European etherealists are quite a bit more complicated. Europeans, of course, are bourgeois themselves, even more so in some ways than Americans and Israelis. What they distrust about America and Israel is that these countries represent a particularly aggressive and, to them, unbalanced strain of bourgeois ambition. No European would ever acknowledge the category, but America and Israel are heroic bourgeois nations. The Israelis are driven by passionate Zionism to build their homeland and make it rich and powerful. Americans are driven by our Puritan sense of calling, the deeply held belief that we Americans have a special mission to spread our way of life around the globe. It is precisely this heroic element of ordinary life that Europeans lack and distrust.

So the Europeans are all ambivalence. The British historian J.H. Plumb once declared that he loved America (and he was indeed a great defender of the United States), but even his admiration for the country "was entangled with anger, anxiety and at times flashes of hate." In his infuriatingly condescending and ultimately appreciative portrait "America," the French modernist Jean Baudrillard wrote, "America is powerful and original; America is violent and abominable. We should not seek to deny either of these aspects, nor reconcile them."

But Europeans do seek to deny them--because they simply can't remember what it's like to be imperially confident, to feel the forces of history blowing at one's back, to have heroic and even eschatological aspirations. Their passions have been quieted. Their intellectual guides have taught them that business is ignoble and striving is vulgar. Their history has caused them to renounce military valor (good thing, too) and to regard their own relative decline as a sign of greater maturity and wisdom. The European Union has a larger population than the United States, and a larger GDP--and its political class has tried to construct an institutional architecture that will enable it to rival America. But the imperial confidence is gone, along with the youthful sense of limitless possibility and the unselfconscious embrace of ordinary striving.

So their internal engine is calibrated differently. They look with disdain upon our work ethic (the average American works 350 hours a year--nearly nine weeks--longer than the average European). They look with disdain upon what they see as our lack of social services, our relatively small welfare state, which rewards mobility and effort but less gracefully cushions misfortune. They look with distaste upon our commercial culture, which favors the consumer but does not ease the rigors of competition for producers. And they look with fear upon our popular culture, which like some relentless machine seems designed to crush the local cultures that stand in its way.

To European bourgeoisophobes, America is the radioactive core of what Ignacio Ramonet, editor and publisher of Le Monde Diplomatique, recently called "The Other Axis of Evil" in a front-page essay. It controls the IMF and the World Bank, the institutions that reward the rich and punish the poor, Ramonet claimed. American institutions such as the Heritage Foundation, the American Enterprise Institute, and the Cato Institute promulgate the ideology that justifies exploitation, he continued. The American military provides the muscle to force-feed economic liberalism to the world.

They look at us uncomprehendingly when our leaders declare a global assault on terror and evil. They see us as a mindless Rambo, a Mike Tyson with rippling muscles and no brain. Where the Islamists see us as a decadent slut, the European etherealists see us as a gun-slinging cowboy. The Islamists think we are too spoiled and comfortable, the Europeans think we are too violent and impulsive. Each side's view of us is a mix of Hollywood images (Marilyn Monroe for the Islamists, John Wayne for the Europeans), mass-media distortions, envy-driven stereotypes, and self-justifying delusions. But each side's vision springs from a deeper bourgeoisophobia--the prejudice that people who succeed in worldly affairs must be morally and intellectually backward. This article of faith governs the way even many sophisticated Europeans and Muslims react to us.



AFTER SEPTEMBER 11, there was a widespread fear in Europe and in certain American circles that the United States would lash out violently and pointlessly. In fact, the United States has never behaved this way. It was slow to respond to Pearl Harbor; it was too timid in its responses to the USS Cole and other attacks. But to many Europeans, who must believe in our mindless immaturity in order to look themselves in the mirror each morning, it was obvious that the United States would shoot first and think afterwards.

These Europeans have assigned themselves the self-flattering role of being Athens to our Rome. That's what all the talk about coalition-building is about; the mindless American car dealer with the big guns should allow himself to be guided by the thoughtful European statesman, who is better able to think through the unintended consequences of any action, and to understand the darker complexities. Much European commentary about America since September 11 has had a zoological tone. The American beast did not know that he was vulnerable to attack (we Europeans have long understood this). The American was traumatized by this discovery. The American was overcompensating with an arms build-up that was pointless since, with his gigantisme militaire, he already had more weapons than he could ever need.

Furthermore, the American doesn't see the deeper causes of terrorism, the poverty, the hopelessness. America should really be spending more money on foreign aid (it's interesting that Europeans, who are supposed to be less materialistic than we are, inevitably think more money can solve the world's problems, while Americans tend to point to religion or ideas).

"What America never takes a moment to consider is that, despite its mightiness, it is a young country with much to learn. It had no real direct experience of the First and Second World Wars," declared a writer in the New Statesman, echoing a sentiment that one heard across the Continent as well. America, many Europeans feel, has no experience with the Red Brigades, the IRA, the Basque terrorists. Americans have no experience with Afghanistan. The dim boobies have no idea what sort of instability they are about to cause. They will go marching off as they always do, naively confident of themselves, yet inevitably unaware of the harm they shall do. Much of the reaction, in short, has been straight out of Graham Greene's novel "The Quiet American." The hero of that book, Alden Pyle, is a well- intentioned, naive, earnest manchild who dreams of spreading democracy but only stirs up chaos. "I never knew a man who had better motives for all the trouble he caused," one of the characters says about him. Much of the European intellectual response to the American war has less to do with actual evidence than with figures from literature and the mass media. Sometimes you get the impression that the only people who took the images of Rambo, the Lone Ranger, and Superman seriously were the European bourgeoisophobes who needed cliches to hate.

When the etherealized bourgeoisophobe goes to practice politics, he instinctively dons the pinstripes of the diplomat. Diplomacy fits his temperament. It demands subtlety instead of clarity, self-control instead of power, patience instead of energy, nuance instead of restlessness. Diplomacy is highly formal, highly elitist, highly civilized. Most of all, it is complex. Complexity is catnip to the etherealized bourgeoisophobe. It paralyzes brute action, and justifies subtle and basically immobile gestures, calibrations, and modalities. Bourgeoisophobes have a simple-minded faith that whatever the problem is, the solution requires complexity. Any decisive effort to change the status quo--to topple Saddam, to give up on Arafat, to foment democracy in the Arab world--will only make things worse.

We Americans have our own bourgeoisophobes, of course. If I pulled from my shelves all the books about the moral backwardness of the enterprising middle classes, I could stack them to the ceiling. I could start with the works of the Transcendentalists, then move through Dreiser, Mencken, Sherwood Anderson, and Sinclair Lewis. Then we could skim swiftly through all the books that bemoan the moral, cultural, and intellectual vapidity of suburbanites, students, middle managers, and middle Americans: "Babbitt," "The Man in the Gray Flannel Suit," "The Souls of Black Folk," "The Lonely Crowd," "The Organization Man," "The Catcher in the Rye," "The Cultural Contradictions of Capitalism," "The Affluent Society," "Death of a Salesman," "Soul on Ice," "The Culture of Narcissism," "Habits of the Heart," "The Closing of the American Mind," "Earth in the Balance," "Slouching Towards Gomorrah," "Jihad vs. McWorld," just about every word ever written by Kevin Phillips and Michael Moore, and just about every novel of the last quarter century, from "Rabbit is Rich" through "The Corrections." It's a Mississippi flood of pessimism. As Catherine Jurca recently wrote in "White Diaspora: The Suburb and the Twentieth-Century American Novel," "As a body of work, the suburban novel asserts that one unhappy family is a lot like the next, and there is no such thing as a happy family."

The pessimism falls into several categories. There is straightforward, left-wing bourgeoisophobia from writers who think commercial culture has ravaged our souls. Then there is the right-wing variant that says it has made us spiritually flat, and so turned us into comfort-loving Last Men. Then there is the conservative pessimism that purports to be a defense of the heroic bourgeois culture America embodies while actually showing little faith in it. Writers of this school argue that the solid capitalist values America once possessed have been corrupted by intellectual currents coming out of the universities--as if the meritocratic capitalist virtues were such delicate flowers that they could be dissolved by the acid influence of Paul de Man.

It all adds up to a lot of dark foreboding, and after September 11, it doesn't look that impressive. The events of the past several months have cast doubt on a century of mostly bourgeoisophobe cultural pessimism. Somehow the firemen in New York and the passengers on Flight 93 behaved like heroes even though they no doubt lived in bourgeois homes, liked Oprah, shopped at Wal-Mart, watched MTV, enjoyed their Barcaloungers, and occasionally glanced through Playboy. Even more than that, it has become abundantly clear since September 11 that America has ascended to unprecedented economic and military heights, and it really is not easy to explain how a country so corrupt to the core can remain for so long so apparently successful on the surface. If we're so rotten, how can we be so great?

It could be, as the bourgeoisophobes say, that America thrives because it is spiritually stunted. It's hard to know, since most of us lack the soul-o-meter by which the cultural pessimists apparently measure the depth of other people's souls. But we do know that despite the alleged savagery, decadence, and materialism of American life, Americans still continue to react to events in ways that suggest there is more to this country than "Survivor," Self magazine, and T.G.I. Friday's.

Confronted with the events of September 11, Americans have not sought to retreat as soon as possible to the easy comfort of their great-rooms (on the contrary, it's been others around the world who have sought to close the parenthesis on these events). President Bush, a man derided as a typical philistine cowboy, has framed the challenge in the most ambitious possible terms: as a moral confrontation with an Axis of Evil. He has chosen the most arduous course. And the American people have supported him, embraced his vision every step of the way--even the people who fiercely opposed his election.

This is not the predictable reaction of a decadent, commercial people. This is not the reaction you would have predicted if you had based your knowledge of America on the extensive literature of cultural decline. Nor would you have been able to predict the American reaction to recent events in the Middle East, which also differs markedly from the European one. Just as the French anti-globalist activist Jose Bove, heretofore most famous for smashing up a McDonald's, senses that he has something in common with Yasser Arafat (whom he visited in Ramallah on March 31), most Americans sense that they have something in common with Israel in this fight. Most Americans can see the difference between nihilistic terrorism and a democracy trying fitfully to defend itself. And most Americans seem willing to defend the principles that are at stake here, even in the face of global criticism and obloquy. In this, as in so much else, George Bush reflects the meritocratic capitalist culture of which he is a product. While the rest of the world was lost in a moral fog, going on about the "cycle of violence" as if bombs set themselves off and the language of human agency and moral judgment didn't apply, the Bush administration, by and large, has been clear.

IN THIS and many other aspects of the war on terrorism, the American leaders and the American people have been stubborn and steadfast. Just as the American people patiently persevered through a century of fighting fascism and communism, there is every sign they will patiently persevere in the conflict against terrorism, which is really a struggle against people who despise our way of life.

Maybe the bourgeoisophobes were wrong from the first. Maybe they were wrong to think that 90 percent of humanity is mad to seek money. Maybe they were wrong to think that wealth inevitably corrupts. Maybe they were wrong to regard themselves as the spiritual superiors of middle-class bankers, lawyers, and traders. Maybe they were wrong to think that America is predominantly about gain and the bitch-goddess success. Maybe they were wrong to think that power and wealth are a sign of spiritual stuntedness. Maybe they were wrong to treasure the ecstatic gestures of rebellion, martyrdom, and liberation over the deeper satisfactions of ordinary life.

And if they weren't wrong, how does one explain the fact that almost all their predictions turned out to be false? For two centuries America has been on the verge of exhaustion or collapse, but it never has been exhausted or collapsed. For two centuries capitalism has been in crisis, but it never has succumbed. For two centuries the youth/the artists/the workers/the oppressed minorities were going to overthrow the staid conformism of the suburbs, but in the end they never did. Instead they moved to the suburbs and found happiness there.

For two centuries there has been this relentless pattern. Some new bourgeoisophobe movement or figure emerges--Lenin, Hitler, Sartre, Che Guevara, Woodstock, the Sandinistas, Arafat. The new movement is embraced. It is romanticized. It is heralded as the wave of the future. But then it collapses, and the never-finally-disillusioned bourgeoisophobes go off in search of the next anti-bourgeois movement that will inspire the next chapter in their ever-disappointed Perils of Pauline journey.

Perhaps, on the other hand, September 11 will cause more Americans to come to the stunning and revolutionary conclusion that we are right to live the way we do, to be the way we are. Maybe it is now time to put intellectual meat on the bones of our instinctive pride, to acknowledge that the American way of life is not only successful, but also character- building. It inculcates virtues that account for American success: a certain ability to see problems clearly, to react to setbacks energetically, to accomplish the essential tasks, to use force without succumbing to savagery. Perhaps ordinary American life mobilizes individual initiative, and the highest, not just the crassest aspirations. Maybe Baudrillard, that infuriatingly appreciative Frenchman, had it right when he wrote about America, "We [Europeans] philosophize about a whole host of things, but it is here that they take shape. . . . It is the American mode of life, that we judge naive or devoid of culture, that gives us the completed picture of the object of our values."

Because the striking thing is that, for all their contempt, the bourgeoisophobes cannot ignore us. They can't just dismiss us with a wave and get on with their lives. The entire Arab world, and much of the rest of the world, is obsessed with Israel. Many people in many lands define themselves in opposition to the United States. This is because deep down they know that we possess a vitality that is impressive. The Europeans regard us as simplistic cowboys, and in a backhanded way they are acknowledging the pioneering spirit that motivates America--the heroic spirit that they, in the comfort of their welfare states, lack. The Islamic extremists regard us as lascivious hedonists, and in a backhanded way they are acknowledging both our freedom and our happiness.

Maybe in their hatred we can better discern our strengths. Because if the tide of conflict is rising, then we had better be able to articulate, not least to ourselves, who we are, why we arouse such passions, and why we are absolutely right to defend ourselves.

David Brooks is a senior editor at The Weekly Standard.

Table of Contents:  https://www.blogger.com/blog/post/edit/6813612681836200616/3382423676443906063?hl=en

Saturday, November 9, 2019

Santiago is Burning

Santiago Chile is Burning
 
November 9, 2019

Burning Metro Ticket Office

 
As we (son Jimmy, his wife Shenda and I) were planning our trip to Patagonia in South America, I suggested that we go through the international airport of Santiago, Chile rather than Buenos Aires, Argentina.  My reasoning was that there is always some danger when traveling and that we could minimize our risk in Chile compared to Buenos Aires.  Chile has had the reputation of being one of the safest countries in South America, whereas Argentina was less safe.  So, we flew from Houston to Santiago and spent a day exploring that wonderful old city.

It was then that we heard that their modern, well-functioning Metro needed funds for upgrading and maintenance, so the ticket price was increased by about four cents to pay for it.  This was the announced reason for the city riots -- and we were in the big middle of it all.  Oops! 

Burned City Bus

Taking a taxi around the downtown area, we encountered college-aged folks in the streets banging pots -- or whatever would make noise -- in a particular rhythm with two long bangs followed by 3 short ones.  It sent a familiar code that they understood was a part of the Marxist movement protesting this new ticket cost. Some wore masks but most did not.  The ones we saw appeared to be fairly clean-cut youngsters of both sexes who were protesting this apparent ticket-hike injustice.

Fire set in the street

Our cab driver had to take a couple of detours around a burned bus, fires in the street, students marching, military vehicles and clouds of tear gas.

Tear Gas Cloud close to us

When our taxi driver saw a tear gas canister shot from a police truck and it landed in front of us, he pulled a quick U-turn so none of us would be exposed.  Way to go Mr. taxi driver!  I questioned him about the identity of the political organization behind this riot.  My interpretation of what he replied, was that it was not a political demonstration, it was a spontaneous eruption triggered only by ticket price hike.  Hmmm.

Maybe One Million in Crowd

 A couple of days later, the protestors held a march along the Mapocho River parkway in downtown Santiago.  Estimates were that there were one million folks in attendance.


Jim and Shenda celebrating their 31st anniversary on same parkway
 
Before that massive march, we had hiked along this parkway to the tower in the background so we could take the elevator to the top to get a great view of the surrounding city.  But, because of the turmoil in the city, the tower was closed.  Bummer.

Arson rampant
 
We were becoming more and more nervous about the situation as we watched the local TV stations.  The riots were being shown on many of the channels and clearly, this was no spontaneous riot.  Thugs had set fires to many local stores, especially targeting Lider stores which are owned by Walmart.  People died in those fires.  At least 11 people have died -- most in the burned supermarkets.  Some of these amateur and "innocent" protestors had now turned into arsonists and murderers.

Was this a political message being sent to the USA?  Of course, I claim no expertise on the political battles of Chile and I cannot know all the characters in this drama.  But, often, when well-meaning kids start a protest like this one, some bad actors join in and the thuggish behavior begins.  Or, it is also possible that socialist thugs planned this action and the kids who joined functioned as "useful idiots" -- a term used to describe non-ideologues who provide assistance to the bad guys because it has suddenly become the popular thing to do.

Cancelled Flights
 
Anyway, as we checked our flight leaving Santiago, it became obvious that many flights had been cancelled and we began to worry about our flight to Patagonia. We had no desire to spend another night in this city that was looking more and more like a war zone.

Santiago's Crowded Terminal
 
This huge Santiago Airport was crowded with folks trying to get out of town, and many found their flights cancelled.  Over 200 domestic and international flights were cancelled by our LATAM airlines. 

That's when Shenda took over for us.  Being the expert traveler that she is, she found her way through the dense crowds to the boarding pass machines and found that our flight had somehow not been cancelled.  Hooray!  With great relief, we boarded our flight and could finally relax as we flew down the Andes mountains to Patagonia. 

Interestingly, when President Pinera of Chile rescinded the four cent hike on the price of a Metro ticket, the rioting did not stop.  The armed forces were mobilized and the local jails began to be filled with the rioters.  Now the goals changed.  If the President would resign, maybe they would stop rioting.  Chile, which has been a model of stability and prosperity in Latin America, now appears to have a shaky future.  The modern Communist Che Guevara is out there somewhere and destined to turn a march into a full scale revolution.  So sad!


Tuesday, November 5, 2019

Shenda Baker Interview

Startups in materials: an interview with Shenda Baker

January 22, 2013 By Stefano Tonzani Leave a Comment

Soft polymeric materials can easily conform to and be made compatible with living tissues, and have thus great potential for biomedical applications.
 

Our interview series on materials scientists turned entrepreneurs continues with Shenda Baker, a professor at Harvey Mudd College on leave who is currently full-time at Synedgen, a startup striving to commercialize polymers for healthcare. Shenda is also at present on the Board of Directors of the Materials Research Society.

1)      Can you give me a brief pitch about what the main product of your company (Synedgen) is, and what is its purpose?
Synedgen is an innovative pharmaceutical company that modifies natural polysaccharides to control and modulate inflammation, tissue regeneration and infection. We have a great, but small, team of scientists and consultants who are committed to the success of Synedgen.
Using polymer chemistry and physics, we have designed molecules that disrupt mucus (for patients who have chronic build up of mucus in their lungs due to a genetic defect) or that break up bacterial biofilms that cause chronic, non-healing wounds and infections. As a biomimetic, we can design the polymer to act like defensins and antimicrobial peptides, molecules produced by our cells to control inflammation and infection.We use a natural biopolymer and modify its properties to target areas of the body or therapeutic targets in the skin, oral cavity, gastrointestinal tract, lungs and eyes.
No polymeric drugs have been approved by the FDA (Food and Drug Administration) except for protein biologics (Editor’s note: biologics are defined as being created by biological processes, rather than chemical synthesis), peptides, or vaccines, and the FDA has declared that our polysaccharides are not “biologics”. Therefore, our polymers will be treated as small molecule drugs, which will be a challenge. Yet they will provide a completely new approach to mitigating infections and reducing inflammation.
2)      What is your role within the company? How different do you feel that the role you play within Synedgen is, with respect to having the same job at a large, established company?
I am President, Chief Operating Officer, and co-founder of Synedgen. In a start-up, the role of President (or CEO) is less defined than, and not as well financially supported as, in a large established company for all the reasons that one knows about wearing all hats. Funds are tight, travel is limited (particularly on government grants), and weekends, holidays, and nights belong to ensuring that the company survives. However, in addition to raising funds and thinking about the big picture goals and implications, I have direct, daily access to and input into the science, the business development, the manufacturing, regulatory process… it is an incredible learning experience.
3)      When did you figure out that there was a good opportunity for commercial exploitation of this discovery/material?
We started exploring the properties of these modified biopolymers and found that they exceeded our expectations. In 2007, my sabbatical focused on better syntheses and better control of the polymer product we had invented in 2004. The in vitro studies were excellent, but our preliminary animal studies, the first in 2006, were outstanding. In 2009, I took a leave of absence from Harvey Mudd College to help push Synedgen to the next phase. By 2009, it was clear that the potential for the suite of polymer drugs we had created could have a dramatic impact on human health. It has been an exciting roller coaster of discovery, process and fundraising ever since.
4)      How long was the process from the “idea” to the creation of the company? Can you give me a detailed breakdown (R&D, IP protection, setting up the company…)?
The idea came across a cocktail napkin (literally) in 2004, and two founders (Dr. William Wiesmann and me) were writing patents in late 2005. Patents are an important ongoing investment. In 2006 we had set up a small space in southern California and worked with our partner manufacturing company until 2009, when we merged to become Synedgen. Our animal and ex vivo data is compelling and we do not need to invest much more in non-human demonstration for our first products. Thus, if we can raise the funds we need to cross the pharmaceutical valley of death (the safety pharmacology and toxicology studies), we could be in human trials by 2014. So, 10 years from invention to first in humans.  Our rate of progress is very much dependent on how quickly we can bring in funds.
5)      Where did you turn for funding? If you used venture capital, was it difficult to get funded outside the “traditional” geographical locations of venture capital firms?
We have been very fortunate to have primarily government funding supplemented by “friends and family” investments. About 90% of our funding so far is from the Army, DARPA and NIH. It is imperative to have private, unrestricted funding in a small company to pay for corporate lawyers, taxes, IP, etc., use of funds that the government strictly prohibits. We have been blessed by a small group of shareholders that understands our product, and by great animal data that makes the grant proposal writing easier. At this point, we have two products that are not human drug products that could generate some revenue, but we will need to be creative to get to the human drug products. Our mission now is to find strategic partners who will work with us to bring this new class of drug products to market. We are eager to transition to a self-sufficient company through products and partnerships.

6)      Before starting this venture, did you want to become an entrepreneur?
I have always loved innovation and the idea that what I developed in the laboratory could have real application. But I never consciously sought to be anything other than a professor. The transition to an entrepreneur was a relatively slow evolution. The potential of inventing and making a product that could mitigate human suffering and save lives is pretty compelling –to see it as a potential actuality in my lifetime rather than a downstream consequence was sufficient to pull me away.
7)      What is the main change in mindset that this venture brought to you? What is the most important thing you could not have possibly understood had you not started your own company?
I had no conception about either the pharmaceutical industry or the tremendously volatile nature of a small business, from my academic perspective. Of course, we have all heard about the ~1 in 10 success rate of small start-up companies, but the multitude of reasons that a good company with good ideas fails is astonishing. I could not have possibly understood the hurdles and costs involved in keeping a good idea protected with IP, demonstrating efficacy in multiple (accepted) animal models, manufacturing under the constraints of current Good Manufacturing Processes, wading through the FDA regulatory process, adapting the good idea into something that will be accepted by those who make funding and regulatory decisions. It is easy to envision how a significant breakthrough could change how we treat infections and tissue inflammation; it is another thing altogether to truly understand how to get that product to the human healthcare market.
8)      Why did you decide to dedicate yourself full time to the company, as opposed to remaining an academic scientist and working on the company “on the side”/consulting/…?
This is a question I often ask myself! However, I had the right skill set and an excellent mentor to understand the science from multiple perspectives, do strategic planning and manage the growing team. Most importantly for me, we keep discovering different properties of this set of molecules that mimic very complicated and ancient biological systems. Much of my job is very much like an academic research environment, and the science is compelling. I do a lot of teaching as every proposal, presentation and briefing is centered on bringing the audience to understanding the uniqueness of our approach as well as its centrality in biological responses.  The transition took 3-4 years before I was fully committed to the company. But it became fully engrossing.
9)      Do you still work on scientific projects unrelated to the company, but linked to your previous academic career? (And/or what do you miss about academia, if anything)
I enjoy collaborating with academic partners, and am maintaining some of those relationships (I hope) and perhaps developing some new ones by actively participating on the Board of Directors of the Materials Research Society. I miss the slower pace of academia and the regular structure of the year, but I miss students the most. Still, I get to overlap my academic and industrial lives a little more as we work regularly with academic collaborators and we are seeking researchers to help model one of the hypothetical interactions of our molecule –a polyionic, entropically driven displacement system that should be a lot of fun to map into the data we observe. Still, the creation of structure and new relationships built around the ever changing process in getting our products closer to human trials motivates me in new ways I had not experienced in my academic career.
10)   How do you juggle your time among the different needs of the company (necessity to develop the product on one side, and to raise funds/look for customers on the other)?
In a small start-up, it is quite the juggling show, and the rule of many hats is not overstated, not just for me but for all of our dedicated staff. Not surprisingly, days are very long in the office, on the road and on the phone, particularly because we have collaborators around the world from Boston to Japan to Dublin. As President of Synedgen, the best balance I can do is to recognize what skills I have that are not reproduced in the company, focus there, and allocate often.
11)   Do you still publish in the open scientific literature, and what value do you think scientific publishing has for a scientist in industry or for a startup?
Synedgen has just begun to publish actively, and it is a very important and validating process for a startup. We had to get all of our patents and even subsequent patents submitted before having the confidence to publish. With the new US rules regarding not first to invent, but first to patent, there is even more concern about holding ideas close until the original concept as well as potential spin off and secondary concepts can also be patented. However, if a startup is funded primarily through government grants including NIH, then publications generate tremendous validating credibility. Patents are not peer reviewed, and thus to some panels and grant reviewers, are only suggestive of useful science. For us, it’s a tough balance because we would like to publish more, but get nervous when we actually think about the details that we would publish.

Table of Contents:  https://www.blogger.com/blog/post/edit/6813612681836200616/3382423676443906063?hl=en